




{"id":7004,"date":"2023-12-20T17:14:37","date_gmt":"2023-12-20T16:14:37","guid":{"rendered":"https:\/\/www.dr-mamczur.pl\/blog\/?p=7004"},"modified":"2023-12-23T09:35:24","modified_gmt":"2023-12-23T08:35:24","slug":"czlowiek-z-choroba-parkinsona-pachnie-pizmem","status":"publish","type":"post","link":"https:\/\/www.dr-mamczur.pl\/blog\/2023\/czlowiek-z-choroba-parkinsona-pachnie-pizmem\/","title":{"rendered":"Cz\u0142owiek z chorob\u0105 Parkinsona pachnie pi\u017cmem."},"content":{"rendered":"<p>W Gazecie lekarskiej\u00a0 7.12. 2022 zaprezentowano artyku\u0142 <a href=\"https:\/\/gazetalekarska.pl\/?p=68998\" target=\"_blank\" rel=\"noopener\">Zapach Parkinsona<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>Na tej podstawie opracowano test <strong>wymazow<\/strong>y pozwalaj\u0105cy z 95% skuteczno\u015bcia wykry\u0107 predyspozycje do choroby Parkinsona.<\/p>\n<p>Bardzo rzetelne opracowanie problemu zapachu cz\u0142owieka przedstawi\u0142a w autorka\u00a0 videobloga emce (nie ma nazwiska)<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=BJyR16--JGU\" target=\"_blank\" rel=\"noopener\">pt.&#8221; Czy da si\u0119 pozna\u0107 chorob\u0119 po zapachu&#8221;<\/a><\/p>\n<p>W filmie wspomniano o piel\u0119gniarce Joy Milne. Prof. Perdita Barran (zajmuj\u0105ca si\u0119 spektrometri\u0105 mas w Manchester Institute of Biotechnology na Uniwersytecie w Manchesterze- Anglia) i Joy Milne pracuj\u0105 nad sposobami poprawy diagnozowania <strong>choroby Parkinsona<\/strong>. Joy Milne to \u201esuper w\u0105chacz\u201d. Cierpi na rzadk\u0105 chorob\u0119, zwan\u0105 hiperosmi\u0105, kt\u00f3ra daje niezwykle wra\u017cliwy w\u0119ch.z nadwra\u017cliwym w\u0119chem (hiperosmi\u0105), kt\u00f3ra zauwa\u017cy\u0142a, \u017ce jej m\u0105\u017c wydziela silny,\u00a0 st\u0119ch\u0142y (pi\u017cmowy) zapach potu. Podobny zapach zaobserwowa\u0142a u pacjent\u00f3w z choroba Parkinsona. gazowej potwierdzi\u0142y, \u017ce pacjenci z t\u0105 chorob\u0105 w sebum wydzielaj\u0105:<strong> ikozan, kwas hipurowy, oktadekanal. Zmniejszone wydzielanie z potem dotyczy\u0142o aldehydu perylowego.<\/strong><\/p>\n<p>Diagnostyka olfaktoryczna<\/p>\n<p>Opr\u00f3cz pi\u017cmowego zapachu w chorobie Parkinsona w prezentacji podano- zapach przy: zaka\u017ceniach Helicobacter pylori -st\u0119chlizna z ust<\/p>\n<p>infekcje intymne(up\u0142awy w grzybicy pochwy) grzy u kobiet &#8211; zapach ryb<\/p>\n<p>gru\u017alica pachnie przele\u017ca\u0142ym piwem<\/p>\n<p>dur brzuszny &#8211; zapach \u015bwie\u017cego chleba,<\/p>\n<p>cukrzyca z ketoza &#8211; zapach acetonu<\/p>\n<p>czerniak tresuj\u0105c myszy uda\u0142o sie wykry\u0107 czerniaka w 87% przypadk\u00f3w<\/p>\n<p>Autorka powo\u0142uje si\u0119 na liczne <span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">\u0179r\u00f3d\u0142a: <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Bushdid, C., Magnasco, M. O., Vosshall, L. B., &amp; Keller, A. (2014). Humans Can Discriminate More than 1 Trillion Olfactory Stimuli. Science, 343(6177), 1370\u20131372. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Olender, T., Lancet, D., &amp; Nebert, D. W. (2008). Update on the olfactory receptor (OR) gene superfamily. Human Genomics, 3(1), 87.<\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\"> Drupad K. Trivedi, Eleanor Sinclair, Yun Xu, Depanjan Sarkar, Caitlin Walton-Doyle, Camilla Liscio, Phine Banks, Joy Milne, Monty Silverdale, Tilo Kunath, Royston Goodacre, and Perdita Barran, Discovery of Volatile Biomarkers of Parkinson\u2019s Disease from Sebum, ACS Central Science 2019 5 (4), 599-606.<\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\"> Niimura, Y. (2009). Evolutionary dynamics of olfactory receptor genes in chordates: interaction between environments and genomic contents. Human Genomics, 4(2), 107. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Porter, J., Craven, B., Khan, R. et al. Mechanisms of scent-tracking in humans. Nat Neurosci 10, 27\u201329 (2007). <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">D\u2019Hulst, C., Mina, R. B., Gershon, Z., Jamet, S., Cerullo, A., Tomoiaga, D., \u2026 Feinstein, P. (2016). MouSensor: A Versatile Genetic Platform to Create Super Sniffer Mice for Studying Human Odor Coding. Cell Reports, 16(4), 1115\u20131125. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Gulbicki P., Skrzydlaci celnicy na londy\u0144skim lotnisku, tydzie\u0144 Smarz W., Mo\u017cliwo\u015bci wykorzystania pszcz\u00f3\u0142 miodnych w procesie wykrywczym, Kwartalnik policyjny 3\/2018. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Krywko J., Pszczo\u0142y lepiej ni\u017c psy potrafi\u0105 wykrywa\u0107 narkotyki i materia\u0142y wybuchowe, Gazeta Wyborcza, 21 listopada 2013. Kokoci\u0144ska-Kusiak A., Identyfikacja zapachowych biomarker\u00f3w czerniaka w moczu myszy, z zastosowaniem metod behawioralnych i analitycznych. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Nadulska, A., Borowicz, P., Psychofizyka w\u0119chu &#8211; zapach jako niewidzialny kod komunikacji spo\u0142ecznej, Psychospo\u0142eczne aspekty postrzegania zdrowia i urody, rozdzia\u0142 IX, WSSP im. Wincentego Pola w Lublinie; 2016. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Teodoro-Morrison, T., Diamandis, E. P., Rifai, N., Weetjens, B. J. C., Pennazza, G., de Boer, N. K., &amp; Bomers, M. K. (2014). Animal Olfactory Detection of Disease: Promises and Pitfalls. Clinical Chemistry, 60(12), 1473\u20131479. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Jenkins, E. K., DeChant, M. T., &amp; Perry, E. B. (2018). When the Nose Doesn&#8217;t Know: Canine Olfactory Function Associated With Health, Management, and Potential Links to Microbiota. Frontiers in veterinary science, 5, 56. <\/span><span class=\"yt-core-attributed-string--link-inherit-color\"><a class=\"yt-core-attributed-string__link yt-core-attributed-string__link--display-type yt-core-attributed-string__link--call-to-action-color\" tabindex=\"0\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbW5oYzM5Zl9zTVFKY3JfOHhfZEZyNndQV3ZHQXxBQ3Jtc0tteXZOT3FPUFNxNUJSU0Z6aVlMRzZHMDF3YXdjYUEycUdrbHJjNGMtMUJxSlVpSWFza3JDSkhBQ3JNbUhtZEJoZWFCRHJKLTNucTY3R0ZDRDJGQ0wwbW5LcVN0UUFORjJGX0tPWHhMMEcxYzlGRGpKbw&amp;q=https%3A%2F%2Fdoi.org%2F10.3389%2Ffvets.2018.00056&amp;v=BJyR16--JGU\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.3389\/fvets.2018.00056<\/a><\/span><span class=\"yt-core-attributed-string--link-inherit-color\"> McCulloch M., Jezierski T., Broffman M., Hubbard A., Turner K., Janecki T. 2006. Diagnostic Accuracy of Canine Scent Detection in Early-and Late-Stage Lung and Breast Cancers. Integrated Cancer Therapy <\/span><span class=\"yt-core-attributed-string--link-inherit-color\"><a class=\"yt-core-attributed-string__link yt-core-attributed-string__link--display-type yt-core-attributed-string__link--call-to-action-color\" tabindex=\"0\" href=\"https:\/\/www.youtube.com\/watch?v=BJyR16--JGU&amp;t=330s\" target=\"\" rel=\"nofollow noopener\">5:30<\/a><\/span><span class=\"yt-core-attributed-string--link-inherit-color\">-39. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Sonoda H., Kohnoe S., Yamazato T., Satoh Y., Morizono G., Shikata K., Morita M., Watanabe A., Morita M., Kakeji Y., Inoue F., Maehara Y. 2011. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Colorectal cancer screening with odour material by canine scent detection. Gut 60: 814-819. Jezierski, Tadeusz &amp; Walczak, Marta &amp; Ligor, Tomasz &amp; Rudnicka, Joanna &amp; Buszewski, Bogus\u0142aw. (2015). Study of the art: Canine olfaction used for cancer detection on the basis of breath odour. Perspectives and limitations. Journal of breath research. 9. 027001.<\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Hackner, K., Errhalt, P., Mueller, M. R., Speiser, M., Marzluf, B. A., Schulheim, A., \u2026 Doll, T. (2016). Canine scent detection for the diagnosis of lung cancer in a screening-like situation. Journal of Breath Research, 10(4), 046003. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Farraia, M. V., Cavaleiro Rufo, J., Paci\u00eancia, I., Mendes, F., Delgado, L., &amp; Moreira, A. (2019). The electronic nose technology in clinical diagnosis: A systematic review. Porto biomedical journal, 4(4), e42. <\/span><\/span><\/p>\n<p><span class=\"yt-core-attributed-string yt-core-attributed-string--white-space-pre-wrap\"><span class=\"yt-core-attributed-string--link-inherit-color\">Skowron M., Grabowska-Polanowska B., Faber J., \u015aliwka I., Zarys metod analitycznych w badaniach oddechu dla cel\u00f3w diagnostyki medycznej.<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>W Gazecie lekarskiej\u00a0 7.12. 2022 zaprezentowano artyku\u0142 Zapach Parkinsona. &nbsp; Na tej podstawie opracowano test wymazowy pozwalaj\u0105cy z 95% skuteczno\u015bcia wykry\u0107 predyspozycje do choroby Parkinsona. Bardzo rzetelne opracowanie problemu zapachu cz\u0142owieka przedstawi\u0142a w autorka\u00a0 videobloga emce (nie ma nazwiska) pt.&#8221; &hellip; <a href=\"https:\/\/www.dr-mamczur.pl\/blog\/2023\/czlowiek-z-choroba-parkinsona-pachnie-pizmem\/\">Czytaj dalej <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.dr-mamczur.pl\/blog\/wp-json\/wp\/v2\/posts\/7004"}],"collection":[{"href":"https:\/\/www.dr-mamczur.pl\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.dr-mamczur.pl\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.dr-mamczur.pl\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dr-mamczur.pl\/blog\/wp-json\/wp\/v2\/comments?post=7004"}],"version-history":[{"count":5,"href":"https:\/\/www.dr-mamczur.pl\/blog\/wp-json\/wp\/v2\/posts\/7004\/revisions"}],"predecessor-version":[{"id":7009,"href":"https:\/\/www.dr-mamczur.pl\/blog\/wp-json\/wp\/v2\/posts\/7004\/revisions\/7009"}],"wp:attachment":[{"href":"https:\/\/www.dr-mamczur.pl\/blog\/wp-json\/wp\/v2\/media?parent=7004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dr-mamczur.pl\/blog\/wp-json\/wp\/v2\/categories?post=7004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dr-mamczur.pl\/blog\/wp-json\/wp\/v2\/tags?post=7004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}